Do you have amyloidosis and looking for who to run to? If yes, you have run to the right place. Here we will offer you the best treatment to deal with amyloidosis symptoms. But firstly, why not medical treatment? Read to the end to discover the best treatment for you.
Can amyloidosis be treated?
Amyloidosis can and should be treated, but the management depends on the type of disease. In the case of AA amyloidosis, the inflammation that caused it should be combated. In AL amyloidosis, chemotherapy is the treatment of choice.
WHAT IS THE BEST TREATMENT FOR AMYLOIDOSIS?
The treatment of amyloidosis is based on the form of the disease.
HERBAL TEA FOR AMYLOIDOSIS
Our treatment is not intended to completely treat the disease but rather to slow its progression and relieve the various symptoms of the disease. Indeed the natural remedy that we offer consists of plants with anti-inflammatory properties. It will also purify your blood and its diuretic properties will be beneficial to you if you have a disease of the kidneys, lymph nodes, and spleen. For people suffering from affection to the nervous and cardiovascular system, these plants will restore the functioning of these different systems. Our treatment is an all in one for the treatment of amyloidosis. This treatment is more affordable than medical treatment.
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OBJECTIVE OF MEDICAL Treatment of amyloidosis
Treatment of amyloidosis is two-fold. On the one hand, it involves alleviating symptoms to maintain a good quality of life for patients, on the other - therapy to inhibit the production of amyloid protein. The treatments currently proposed can change the natural course of the disease, provided they are implemented before irreversible organ damage occurs. Early diagnosis, proper selection of amyloid, inclusion of appropriate treatment of the underlying disease adapted to the risk level, close observation and supportive treatment are crucial for the effectiveness of therapy. The localized form of amyloidosis requires radiotherapy or surgery, generalized amyloidosis and systemic treatment.
TREATMENT OF AL AMYLOIDOSIS
For the most effective but also the most aggressive method of treatment - high-dose chemotherapy followed by autologous bone marrow stem cell transplantation ( ASCT)) - patients are eligible in good general condition without serious heart damage. In some cases, if there is an increased percentage of plasmacytes in the bone marrow> 10%, treatment starts with chemotherapy, and the ASCT procedure begins after a few months, after reducing the infiltration in the bone marrow.
Other drugs used to date for myeloma are also being studied in amyloidosis. These include, but are not limited to, immunomodulatory drugs such as lenalidomide. Caution in their introduction is caused, among others, by a higher risk of side effects than in myeloma.
WHAT IF THE TREATMENT DOESN'T WORK OR THE DISEASE RECURS?
For relapsed or refractory disease, various myeloma therapy regimens are adapted. These include combinations based on bortezomib, lenalidomide, bendamustine, as well as new drugs such as daratumumab, pomalidomide and ixazomib. The latest drugs are only available as part of clinical trials.
TREATMENT OF OTHER FORMS OF AMYLOIDOSIS
The drug directly affecting the accumulation of deposits in AA amyloidosis is currently in the sphere of research. The greatest emphasis in therapy is put on removing the cause of the formation of SAA amyloid, which is chronic inflammation.
In amyloidosis AF, so-called drugs are being tested. stabilizers of amyloid proteins (diflunisal, tafamidis), preventing the transformation of the correct TTR protein into amyloid. In some situations, liver transplantation is considered.
The management of senile amyloidosis is mainly aimed at alleviating its symptoms, but some efficacy of diflunisal or tafamidis is also observed.
For cardiac involvement in AF and AS amyloidosis, doxycycline is also given.
ORGAN TRANSPLANTATION
Organ transplantation in place of those irreversibly damaged by amyloidosis is technically possible. However, it is considered when at least a very good partial hematological response was obtained after the hematological treatment described briefly above (VGPR). Otherwise, the risk that the transplanted organ would be quickly destroyed by the disease is too high. Heart transplantation is a serious procedure, it can only be offered to young patients. Kidney transplants are performed much more often. Attempts are also being made to liver transplantation, but here, apart from congenital amyloidosis, the effects are much worse.
HOW IS AMYLOIDOSIS DETECTED?
Amyloidosis assumed on the basis of clinical and laboratory data must be confirmed morphologically by the detection of amyloid in tissue biopsies.
If AL-type amyloidosis is suspected, bone marrow puncture is recommended. The counting of plasma cells and the staining of punctate on amyloid allows not only to diagnose amyloidosis, but also to differentiate the primary and associated with myeloma variants of AL-amyloidosis. A positive result of a study of bone marrow on amyloid was observed in 60% of patients with AL-amyloidosis.
A simple and safe diagnostic procedure is an aspiration biopsy of subcutaneous fat, in which amyloid is detected in 80% of cases of AL-amyloidosis. The advantages of this procedure, in addition to informativeness, also include the rarity of bleeding, which makes it possible to use this method in patients with blood coagulation disorders (patients with primary amyloidosis often have a coagulation factor X deficiency in which hemorrhages can develop).
Most often, for the diagnosis of different types of amyloidosis, a biopsy of the mucous membrane of the rectum, kidney, and liver is performed. A biopsy of the mucous and submucous layers of the rectum allows the detection of amyloid in 70% of patients, and a kidney biopsy in almost 100% of cases. In patients with carpal tunnel syndrome, amyloid examination should be performed on tissue removed during carpal tunnel decompression.
Biopsy material for the detection of amyloid must be stained with Congo red, followed by microscopy in polarized light to detect birefringence. Modern morphological diagnosis of amyloidosis includes not only detection, but also typing of amyloid, since the type of amyloid determines the therapeutic tactics. For typing, a sample with potassium permanganate is often used. When treating Congo-stained red preparations with a 5% potassium permanganate solution, the AA-type amyloid loses its color and loses the birefringence property, while the AL-type amyloid retains them. The use of alkaline guanidine makes it possible to more accurately differentiate AA and AL amyloidosis.
The most effective method for typing amyloid is an immunohistochemical study using antisera to the main types of amyloid protein (specific antibodies against AA protein, immunoglobulin light chains, transthyretin and beta-2-microglobulin).
HOW LONG CAN YOU LIVE WITH THIS DISEASE?
With untreated AL amyloidosis, survival is short, about a year, and up to six months with severe heart damage. It is doubled when used. It should be remembered that the earlier the diagnosis is made and the treatment is initiated, the greater the chances of a long survival.
In AA amyloidosis, the average survival exceeds 10 years. Extinguishing the inflammation stops or slows down the process of amyloid deposition, which significantly improves the prognosis.
In amyloidosis AF, the average survival is estimated at 5-15 years from the time of diagnosis.
Our expert's opinion: A balanced diet is very important for the body's energy supply. Although amyloid is a protein, changing the amount of protein consumed does not affect the course of the disease. However, you may need a special diet depending on the symptoms and organs involved (e.g. kidney or liver damage).
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